1.3.11 Explain the course of events that leads to atherosclerosis (endothelial damage, inflammatory response, plaque formation, raised blood pressure).

Damage to endothelial lining of artery causes inflammation, this initiates the blood clotting process/ inflammatory response: white blood cells move into the artery wall, cholesterol builds up, atheroma forms, calcium, salts and fibres build up, plaques form, artery narrows; raising blood pressure, causing further damage to endothelial lining and an increased risk of blood clotting in the artery. Incase the atheroma raptures the artery wall is further damaged and thrombosis is triggered. The process repeats.